Sistema de Eventos Acadêmicos da UFMT, XI Mostra da Pós-Graduação

Tamanho da fonte: 
Inadequate physical exercise in pregnancy-lactating period leads rat-offspring to high vulnerability to obesity in later life
Hercules de Oliveira Costermani, Raul Evangelista de Almeida, Bárbara Letícia Antônio Membrive, Ginislene Dias Souza Miranda, Thalyne Aparecida Leite de Lima, Jocemara Patrícia Silva de Souza Parrela, Camila Luiza dos Santos Rodrigues Ricken, Júlio Cezar de Oliveira

Última alteração: 09-10-19

Resumo


Background: The benefits of regular practice of physical exercise at pregnancy, is pivotal to maternal and babies health. If performed adequately, it can prevents metabolic disorders onset, as well as blocks offspring diseases in later life. Herein we aimed to evaluate two swimming intensity-protocols in pregnant- and lactating-rats upon the rat-offspring body composition. Methods: Wistar pregnant-rats underwent one of swimming protocols, high-intensity exercise (HIE-group; from day 3rd of gestation until the pups weaning, at random sessions that began at morning or afternoon; 30min/day, 4-times a week, without previous adaptation), or moderate-intensity exercise (MIE-group; from one week before pregnancy until the pups weaning; 30min/day, 5-times a week). An overload (5% of body weight) was added in MIE-group during non-pregnant period. The swim adaptation for MIE-group was performed throughout 3 weeks before pregnancy (10min on the first day with an increase of 5min per day, during 5 days). Control pregnant- and lactating-rats did not swim (Cont-group). Rat-offspring received standard rodent chow and water ad libitum from weaning until 100-days-old when were euthanized for biometrical analyzes. Results: Compared to Cont-group, birthweight of MIE-rat-offspring was smaller (11%, P<0.001), while in HIE-rat-offspring it was higher (6%, P<0.01). In relation to Cont-rat-offspring, MIE-rat-offspring was hypophagic (–13%, P<0.05), while HIE-rat-offspring was hyperphagic (18%, P<0.01%). The MIE-rat-offspring presented reduction in Lee index (2%, P<0.05), retroperitoneal (27%, P<0.01), periepididymal (24%, P<0.01) and mesenteric (37%, P<0.001) fat pad, compared to Cont-rat-offspring. By other hand, HIE-rat-offspring displayed increase in Lee index (2%, P<0.05), retroperitoneal (26%, P<0.01), periepididymal (21%, P<0.01) and mesenteric (27%, P<0.01) fat pad, than Cont-rat-offspring. In relation to Cont-rat-offspring, brown adipose tissue did not change in MIE-rat-offspring (P>0.05), but in HIE-rat-offspring it was 25% smaller (P<0.01). Conclusion: Inadequate maternal physical exercise (high-intensity swimming), at pregnancy and lactation, programs rat-offspring to obesity.

 

Keywords: Swimming, pregnancy, high-intensity exercise, obesity


Palavras-chave


Swimming, pregnancy, high-intensity exercise, obesity