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Tamanho da fonte: 
FOOD-DEPRIVATION IN ADOELSCENCE INDUCES HYPERPHAGIA AS LONG-TERM CONSEQUENCES IN FEMALE RATS EVEN AFTER THE DIETARY HEABILITATION
Amanda Freitas Da Silva, Sara Santos dos Reis, Hercules de Oliveira Costermani, Bárbara Letícia Antonio Membrive, Dayane Oliveira Melo, Ginislene Dias Souza Miranda, Júlio Cezar de Oliveira

Última alteração: 10-10-18

Resumo


Calorie-protein restriction in puberty has been reported by induces malprogramming effects in male rats, leading to obesity and peripheral insulin resistance. On the other hand, a sexual dimorphism has been observed to rodent experimental models in regarding metabolic effects due to malnutrition. Because of this, we aimed to assess the effects of the food deprivation throughout adolescence in female rats on the body growth evolution and food intake behavior after the period scarcity, as long-term consequence. At 30 days old, Wistar female rats were deprived from diet by 50% (FR50 group) of the amount of diet offered to control ones, until 60 days old and then, to dietary rehabilitation, were fed ad libitum from 60- to 120 days old. Control female rats (CONT group) were fed ad libitum during all experimental period. Body weight and food intake were evaluated throughout experimental period to each two days. All Experimental procedures were approved by the research ethical committee for use of animals from the Universidade Federal de Mato Grosso. All data were analyzed by Student t test, through Graph Pad Prism, for Windows. At 60 days old, after starvation period, FR50 rats showed smaller body weight (around of 64%, P<0.001) and as expected hypophagia (–50%, P<0.001) once it was forced to do. By contrast, at 120 days old FR50 rats displayed body weight similar to CONT group. During the dietary rehabilitation period the body weight gain was 2.5-fold higher in FR50 rats than in CONT rats (P<0.001). In addition, during the dietary rehabilitation, the FR50 rats displayed significant hyperphagia in relation to CONT rats (P<0.001). Food restriction in adolescence malprograms female rats to hyperphagia as long-term consequence, which is a risk factor to obesity and metabolic syndrome onset.

Palavras-chave


Metabolic programming, food intake, body weight gain, hyperphagia